Changes in auditory function associated with 2-cyano-butyl-acrylate adhesive implanted in the middle ear of experimental animals

Daniel Zikk*, Yoram Rapoport, Mordechai Z. Himelfarb

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effects on auditory function caused by the implantation of 2-cyano-butyl-acrylate adhesive in the middle ear was investigated in experimental animals. Auditory brainstem responses to click stimuli were used to measure hearing thresholds prior to and following implantation of 2-cya- no-butyl-acrylate adhesive in the middle ear of guinea pigs. A permanent and deep threshold shift observed at 2 months in 62% of the examined animals, suggested that this tissue adhesive is an ototoxic middle ear implant material and should not be considered in reconstructive middle ear surgery. The functional data correlate well with some of the previous morphological observations.

Original languageEnglish
Pages (from-to)179-182
Number of pages4
JournalLaryngoscope
Volume100
Issue number2
DOIs
StatePublished - Feb 1990

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