Challenges of fertility preservation in leukemia patients

Moran Shapira, Hila Raanani, Sanaz Derech Chaim, Dror Meirow*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


An ongoing increase in survival rates among young leukemia patients is accompanied by a growing attention to possible long-term complications such as chemotherapy induced ovarian insuffciency and infertility. Therefore, an important element of the management of these patients is fertility preservation, which is challenged by considerations specifc for leukemia. Such considerations include prepuberty, poor medical condition on presentation and the need for urgent chemotherapy, all of which may preclude the use of conventional assisted reproductive technologies. a restrictive approach towards utilizing cryopreserved ovarian tissue due to the risk for malignancy reintroduction on transplantation, further minimize the options that currently exist for these patients. This paper aims to provide up-to-date knowledge on gonadotoxicity associated with therapy regimens currently used in the treatment of leukemia. Different fertility preservation techniques are discussed, with an emphasis on effcacy, applicability and limitations in the context of leukemia.

Original languageEnglish
Pages (from-to)456-464
Number of pages9
JournalMinerva Ginecologica
Issue number4
StatePublished - Aug 2018


  • Cryopreservation
  • Fertility preservation
  • Leukemia
  • Neoplasm, residual


Dive into the research topics of 'Challenges of fertility preservation in leukemia patients'. Together they form a unique fingerprint.

Cite this