CEST MRI of 3-O-methyl-D-glucose on different breast cancer models

Michal Rivlin, Gil Navon

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To test the ability of chemical exchange saturation transfer (CEST) MRI of 3-O-methyl-D-glucose (3OMG) to detect tumors in several breast cancer models of murine and human origin, for different routes of administration of the agent and to compare the method with glucoCEST and with 18FDG-PET on the same animals. Methods: In vivo CEST MRI experiments were performed with a 7T Biospec animal MRI scanner on implanted orthotopic mammary tumors of mice before and after administration of 3OMG. Results: A marked 3OMG-CEST MRI contrast that was correlated with the administrated dose was obtained in different breast cancer models and by intravenous, intraperitoneal, and per os methods of administration. The most aggressive breast cancer model yielded the highest CEST contrast. 3OMG-CEST contrast reached its maximum at 20 min after administration and lasted for more than an hour, while that of glucose was lower and diminished after 20 min. 3OMG-CEST showed comparable results to that of FDG PET. Conclusion: The sensitivity of the 3OMG-CEST MRI method indicates its potential for the detection of tumors in the clinic. Magn Reson Med 79:1061–1069, 2018.

Original languageEnglish
Pages (from-to)1061-1069
Number of pages9
JournalMagnetic Resonance in Medicine
Volume79
Issue number2
DOIs
StatePublished - Feb 2018

Keywords

  • 3-O-Methyl-D-glucose
  • CEST
  • MRI
  • PET/CT
  • breast cancer
  • chemical exchange saturation transfer

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