TY - JOUR
T1 - Cerebral vein thrombosis in childhood systemic lupus erythematosus
AU - Uziel, Yosef
AU - Laxer, Ronald M.
AU - Blaser, Susan
AU - Andrew, Maureen
AU - Schneider, Rayfel
AU - Silverman, Earl D.
N1 - Funding Information:
Supported in part from a grant from the Ontario Lupus Association and a grant from The Hospital for Sick Children Foundation.
PY - 1995/5
Y1 - 1995/5
N2 - We describe three cases of cerebral vein thrombosis (CVT) in girls with systemic lupus erythematosus. Severe, persistent, unremitting headache was a common manifestation. In the first patient, although the clinical features were suggestive of CVT, the diagnosis was delayed and she had a significant cerebral infarct. In the other two patients the diagnosis was made earlier and led to more rapid treatment; the institution of early therapy may have prevented further sequelae. The CVT was diagnosed in all patients with a combination of computed tomography and magnetic resonance imaging studies without the need for angiography. All patients were treated for their underlying systemic lupus erythematosus and with anticoagulation. All are receiving long-term low doses of warfarin and have not had any recurrences. (J P EDIATR 1995;126:722-7).
AB - We describe three cases of cerebral vein thrombosis (CVT) in girls with systemic lupus erythematosus. Severe, persistent, unremitting headache was a common manifestation. In the first patient, although the clinical features were suggestive of CVT, the diagnosis was delayed and she had a significant cerebral infarct. In the other two patients the diagnosis was made earlier and led to more rapid treatment; the institution of early therapy may have prevented further sequelae. The CVT was diagnosed in all patients with a combination of computed tomography and magnetic resonance imaging studies without the need for angiography. All patients were treated for their underlying systemic lupus erythematosus and with anticoagulation. All are receiving long-term low doses of warfarin and have not had any recurrences. (J P EDIATR 1995;126:722-7).
UR - http://www.scopus.com/inward/record.url?scp=0029020251&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(95)70399-3
DO - 10.1016/S0022-3476(95)70399-3
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C2 - 7751995
AN - SCOPUS:0029020251
SN - 0022-3476
VL - 126
SP - 722
EP - 727
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -