Cerebral sinus venous thrombosis in children with inherited bleeding disorders: A case series

Irtiza N. Sheikh; Lakshmi Srivaths; Emma Li; Orna Steinberg-Shemer; Noa Mandel-Shorer; Gili Kenet; Assaf A. Barg

doi:10.1002/pbc.29902

Cerebral sinus venous thrombosis in children with inherited bleeding disorders: A case series

Irtiza N. Sheikh^*, Lakshmi Srivaths^*, Emma Li, Orna Steinberg-Shemer, Noa Mandel-Shorer, Gili Kenet, Assaf A. Barg

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In patients with inherited bleeding disorders, thrombus development poses a challenge in balancing the management of thrombosis and bleeding. Pediatric antithrombotic therapy guidelines do not address the treatment of a thrombus in the setting of a bleeding disorder. We present a case series of four children with inherited bleeding disorders presenting with cerebral sinus venous thrombosis and bleeding, in order to summarize the different therapeutic approaches and outcomes of these patients.

Original language	English
Article number	e29902
Journal	Pediatric Blood and Cancer
Volume	69
Issue number	10
DOIs	https://doi.org/10.1002/pbc.29902
State	Published - Oct 2022

Keywords

cerebral sinus venous thrombosis
coagulation
hemophilia
inherited bleeding disorder
von Willebrand disease

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10.1002/pbc.29902

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abstract = "In patients with inherited bleeding disorders, thrombus development poses a challenge in balancing the management of thrombosis and bleeding. Pediatric antithrombotic therapy guidelines do not address the treatment of a thrombus in the setting of a bleeding disorder. We present a case series of four children with inherited bleeding disorders presenting with cerebral sinus venous thrombosis and bleeding, in order to summarize the different therapeutic approaches and outcomes of these patients.",

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AU - Steinberg-Shemer, Orna

AU - Mandel-Shorer, Noa

AU - Kenet, Gili

AU - Barg, Assaf A.

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AB - In patients with inherited bleeding disorders, thrombus development poses a challenge in balancing the management of thrombosis and bleeding. Pediatric antithrombotic therapy guidelines do not address the treatment of a thrombus in the setting of a bleeding disorder. We present a case series of four children with inherited bleeding disorders presenting with cerebral sinus venous thrombosis and bleeding, in order to summarize the different therapeutic approaches and outcomes of these patients.

KW - cerebral sinus venous thrombosis

KW - coagulation

KW - hemophilia

KW - inherited bleeding disorder

KW - von Willebrand disease

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Cerebral sinus venous thrombosis in children with inherited bleeding disorders: A case series

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