Cerebral amyloid angiopathy impact on endothelium

Lea Tenenholz Grinberg, Amos D. Korczyn, Helmut Heinsen

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral amyloid angiopathy (CAA) is an age-associated disease characterized by amyloid deposition in cerebral and meningeal vessel walls. CAA is detected in the majority of the individuals with dementia and also in a large number of non-demented elderly individuals. In addition, CAA is strongly associated with Alzheimer's disease (AD) pathology. Mechanical consequences including intra-cerebral or subarachnoid hemorrhage remains CAA most feared complication, but only a small fraction of CAA results in severe bleeding. On the hand the non-mechanical consequences in cerebrovascular regulation are prevalent and may be even more deleterious. Studies of animal models have provided strong evidence linking the vasoactive Aβ 1-40, the main species found in CAA, to disturbances in endothelial-dependent factors, disrupting cerebrovascular regulation Here, we aimed to review experimental findings regarding the non-mechanical consequences of CAA for cerebrovascular regulation and discuss the implications of these results to clinical practice.

Original languageEnglish
Pages (from-to)838-842
Number of pages5
JournalExperimental Gerontology
Volume47
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • Alzheimer's disease
  • Amyloid
  • Angiopathy
  • Animal models
  • Blood brain barrier
  • Cerebrovascular dysfunction
  • Dementia
  • Endothelium

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