Central venous line thrombosis in children and young adults with thalassemia major

Yaron Finkelstein, Isaac Yaniv, Michael Berant, Rama Zilber, Ben Zion Garty, Orit Epstein, Judith Lahav, Hannah Tamary*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


High doses of intravenous deferoxamine via central venous line (CVL) has recently been shown to improve survival in patients with noncompliant thalassemia major (TM). The aim of this retrospective study was to evaluate the extent of CVL-related thrombosis and to determine the presence of prothrombotic factors in children and young patients with TM on such a regimen. Twenty-three patients (median age 13, range 5-25 years) with TM in whom a tunneled CVL was inserted for intensification of iron chelation were evaluated for signs and symptoms of thrombosis and for inherited and acquired risk factors of thrombosis. Mean duration of CVL placement was 37 ± 31 months (range 6-98 months). Eight patients (35%) had CVL-related thrombosis diagnosed clinically or by echocardiography. Nine patients (39%) had prothrombotic factors, but the thrombosis subgroup did not differ from the other group in age, platelet counts, duration of CVL placement, or the presence of predisposing prothrombotic factors. Based on the high rate of CVL-related thrombosis, routine monitoring is suggested for CVL thrombosis in this population.

Original languageEnglish
Pages (from-to)375-381
Number of pages7
JournalPediatric Hematology and Oncology
Issue number5
StatePublished - Jul 2004


  • Central venous line
  • Children
  • Thalassemia
  • Thrombophilia


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