Central precocious puberty after resection of a virilising adrenocortical oncocytic tumour

Lee Rima Madi, Naama Fisch Shvalb, Chen Sade Zaltz, Yael Levy-Shraga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Adrenocortical oncocytic tumours are a histological subtype of adrenal neoplasms with a distinctive morphological appearance. Since these tumours are composed of cells of the adrenal cortex, they may act as functional tumours with excess hormone production. They may cause Cushing's syndrome, inappropriate virilisation or precocious puberty. Though rare during childhood, adrenocortical oncocytic tumours should be suspected in a child with peripheral precocious puberty and marked elevation of dehydroepiandrosterone sulfate levels. We describe a 6-year girl who presented with peripheral precocious puberty due to a functional adrenocortical oncocytic tumour. Three months after tumour removal, she developed true central precocious puberty. This report highlights that peripheral precocious puberty may trigger central precocious puberty, particularly after resolution of the underlying cause of the peripheral precocious puberty.

Original languageEnglish
Article number239562
JournalBMJ Case Reports
Issue number5
StatePublished - 27 May 2021


  • adrenal disorders
  • paediatrics


Dive into the research topics of 'Central precocious puberty after resection of a virilising adrenocortical oncocytic tumour'. Together they form a unique fingerprint.

Cite this