Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma

C. Kaplinsky*, A. Toren, Y. Neumann, M. Mandel, G. Kenet, N. Sharon, G. Rechavi, M. Biniaminov, V. Rubanov, E. Rosenthal, E. Rosner, Z. Mark, N. Amariglio, F. Brok- Simoni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Central nervous system (CNS) involvement in Ki-1/CD30 lymphoma is extremely rare, in contrast to the frequent involvement in other types of pediatric non-Hodgkin's lymphoma. No mechanism has yet been proposed to explain the sparing of the blood brain barrier in Ki-1/lymphoma. We present a 2-year-old boy who was admitted to the Department of Pediatric Hemato- Oncology due to lethargy, progressive breathing difficulties, massive diffuse lymphadenopathy, hepatosplenomegaly, and ichthyosis-like skin involvement with epidermolysis. A lymph node biopsy was compatible with Ki-1/CD30 anaplastic large cell lymphoma (AICI). Bone marrow aspirate and biopsy demonstrated reactive hyperplasia. Cytogenetic analysis displayed hyperdiploid cells with 1p(-) in most cells. Cerebrospinal fluid examination showed pleocytosis with CD30+ cells. Possible mechanisms which could enable CNS involvement in this unusual case are discussed.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalMedical and Pediatric Oncology
Volume28
Issue number2
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Ki-1/CD30 positive lymphoma
  • childhood malignancies
  • non-Hodgkin's lymphoma

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