TY - JOUR
T1 - Central giant cell granuloma associated with central ossifying fibroma of the jaws
T2 - a clinicopathologic study
AU - Kaplan, Ilana
AU - Manor, Ifat
AU - Yahalom, Ran
AU - Hirshberg, Abraham
PY - 2007/4
Y1 - 2007/4
N2 - Objective: To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF). Study design: Retrospective clinical and histomorphometric analysis of all cases diagnosed as CGCG or COF between 1994 and 2002. Results: A total of 51 cases were included in the study: CGCG (n = 23), COF (n = 25), and combined COF-CGCG (n = 3). All 3 lesions presented expansile, well-defined unilocular radiolucencies, with radiopacities (66%), root resorption (66%) and tooth displacement (33%). Microscopically, areas of classical CGCG and COF were separated by a transition zone of nonvascularized densely packed spindle cells. Surgical procedure resulted in recurrence within 1 year in 1 of 2 patients, calcitonin nasal spray treatment resulted in growth arrest in 1 case. Conclusions: Because of the small number of the combined cases, the biologic behavior of the lesions is uncertain. The CGCG component may drive the clinical behavior toward a more aggressive behavior than classical COF; therefore, close follow-up is recommended.
AB - Objective: To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF). Study design: Retrospective clinical and histomorphometric analysis of all cases diagnosed as CGCG or COF between 1994 and 2002. Results: A total of 51 cases were included in the study: CGCG (n = 23), COF (n = 25), and combined COF-CGCG (n = 3). All 3 lesions presented expansile, well-defined unilocular radiolucencies, with radiopacities (66%), root resorption (66%) and tooth displacement (33%). Microscopically, areas of classical CGCG and COF were separated by a transition zone of nonvascularized densely packed spindle cells. Surgical procedure resulted in recurrence within 1 year in 1 of 2 patients, calcitonin nasal spray treatment resulted in growth arrest in 1 case. Conclusions: Because of the small number of the combined cases, the biologic behavior of the lesions is uncertain. The CGCG component may drive the clinical behavior toward a more aggressive behavior than classical COF; therefore, close follow-up is recommended.
UR - http://www.scopus.com/inward/record.url?scp=33947522567&partnerID=8YFLogxK
U2 - 10.1016/j.tripleo.2006.03.017
DO - 10.1016/j.tripleo.2006.03.017
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AN - SCOPUS:33947522567
SN - 1079-2104
VL - 103
SP - e35-e41
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 4
ER -