Center variability in the prognostic value of a cumulative acute cellular rejection “A-score” for long-term lung transplant outcomes

Natalia Belousova*, Ella Huszti, Qixuan Li, Anastasiia Vasileva, Rasheed Ghany, Ramy Gabarin, Moustapha El Sanharawi, Clement Picard, David Hwang, Liran Levy, Shaf Keshavjee, Chung Wai Chow, Antoine Roux, Tereza Martinu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The acute rejection score (A-score) in lung transplant recipients, calculated as the average of acute cellular rejection A-grades across transbronchial biopsies, summarizes the cumulative burden of rejection over time. We assessed the association between A-score and transplant outcomes in 2 geographically distinct cohorts. The primary cohort included 772 double lung transplant recipients. The analysis was repeated in 300 patients from an independent comparison cohort. Time-dependent multivariable Cox models were constructed to evaluate the association between A-score and chronic lung allograft dysfunction or graft failure. Landmark analyses were performed with A-score calculated at 6 and 12 months posttransplant. In the primary cohort, no association was found between A-score and graft outcome. However, in the comparison cohort, time-dependent A-score was associated with chronic lung allograft dysfunction both as a time-dependent variable (hazard ratio, 1.51; P < .01) and when calculated at 6 months posttransplant (hazard ratio, 1.355; P = .031). The A-score can be a useful predictor of lung transplant outcomes in some settings but is not generalizable across all centers; its utility as a prognostication tool is therefore limited.

Original languageEnglish
Pages (from-to)89-103
Number of pages15
JournalAmerican Journal of Transplantation
Volume24
Issue number1
DOIs
StatePublished - Jan 2024

Keywords

  • A-score
  • CLAD
  • acute rejection score
  • chronic lung allograft dysfunction
  • lung transplant
  • prognosis

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