Centenarian stroke treated with tissue-type plasminogen activator

Mark J. Gorman*, David Tanne, Christopher A. Lewandowski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Elderly patients with acute ischemic stroke often do worse than younger counterparts independent of thrombolytic therapy. Further, tissue-type plasminogen activator, (t-PA) is frequently withheld from the very old. This may be the result of comorbid conditions prohibiting its use or possibly the fear of causing more harm than good. We present a case of a 100-year-old woman who was treated with t-PA for acute ischemic stroke with rapid resolution of symptoms. Case Description: A 100-year-old woman presented to the emergency department with slurred speech, right hemiparesis and right hemisensory loss. Computed tomography revealed neither hemorrhage nor early ischemic changes. Intravenous t-PA was administered at 0.9 mg/kg 3 min prior to the 3-hour limit. She improved rapidly (NIHSS from 12 on admission to 4 at 1 month) and was discharged to the care of her family after 4 hospital days. Conclusion: Intravenous thrombolysis may be beneficial in the very elderly and should be considered in any eligible elderly patients with acute ischemic stroke, with a risk/benefit analysis individualized to each case.

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalCerebrovascular Diseases
Issue number4
StatePublished - 2002
Externally publishedYes


  • Elderly
  • Stroke
  • Thrombolysis
  • Tissue-type plasminogen activator


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