Cellular-scale transport in deformed skeletal muscle following spinal cord injury

Yael Ruschkewitz, Amit Gefen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Deep tissue injury (DTI) is a severe pressure ulcer initiating in weight-bearing skeletal muscles. Being common in spinal cord injury (SCI) patients, DTI is associated with mechanical cell damage and ischaemia. Muscle microanatomy in SCI patients is characterised by reduced myofibre sizes and smaller, fewer capillaries. We hypothesise that these changes influence mass transport in SCI muscles, making DTImore probable. Usingmultiphysicsmodels ofmicroscopic cross-sections through normal and SCImuscles, westudied effects of the following factors on transport of glucose andmyoglobin (potential biomarker for early DTI detection): (i) abnormal SCI muscle microanatomy, (ii) large tissue deformations and (iii) ischaemia. We found that the build-up of concentrations of glucose and myoglobin is slower for SCI muscles, which could be explained by the pathological SCI microanatomy. These findings overall suggest that microanatomical changes in muscles post-SCI play an important role in the vulnerability of the SCI patients to DTI.

Original languageEnglish
Pages (from-to)411-424
Number of pages14
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume14
Issue number5
DOIs
StatePublished - 2011

Keywords

  • Deep tissue injury
  • Diffusion
  • Glucose
  • Multiphysics
  • Myoglobin
  • Pressure ulcer

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