Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Uri H. Lewinski; Giora M. Mavligit; Evan M. Hersh

doi:10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Uri H. Lewinski
, Giora M. Mavligit^*
, Evan M. Hersh

^*Corresponding author for this work

University of Texas MD Anderson Cancer Center
University of Texas Health Science Center at Houston

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The effect of a single high dose of Levamisole (200 mg/M²) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

Original language	English
Pages (from-to)	2185-2194
Number of pages	10
Journal	Cancer
Volume	46
Issue number	10
DOIs	https://doi.org/10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5
State	Published - 15 Nov 1980
Externally published	Yes

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10.1002/1097-0142(19801115)46:10<2185::AID-CNCR2820461015>3.0.CO;2-5

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abstract = "The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.",

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AU - Hersh, Evan M.

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N2 - The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

AB - The effect of a single high dose of Levamisole (200 mg/M2) on delayed‐type hypersensitivity (DTH) in vivo and on lymphocyte blastogenesis to mitogens and antigens in vitro was studied in 26 patients with carcinoma. Similar studies were conducted in 24 control patients. Levamisole had a moderate but significant enhancing effect on DTH to Dermatophytin detectable no earlier than eight hours and still present at 48 hours after the drug administration. A moderate but significant enhancing effect on lymphocyte blastogenesis to mitogens and antigens was also demonstrated during the same time sequence. Further clinical trials with Levamisole should be conducted with more attention paid to schedule of drug administration.

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Cellular immune modulation after a single high dose of levamisole in patients with carcinoma

Abstract

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