Cellular functions related to metastasis differing between low- and high-malignancy variants of akr lymphoma

Ofer Klein, Naftali Savion, Alexander Staroselsky, Judith Leibovici*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Two AKR lymphoma variants of low (LM) and high (HM) malignancy were characterized for cell properties important for metastatic capacity. Previous data suggested that these murine lymphoma variants differed in the late phase of metastasis. In the present study we attempted to determine more accurately the stage in which they differ. The HM cells attached less efficiently than the LM ones to both endothelial cells (5 times) and extracellular matrix (twice), possibly indicating a more efficient extravasation capacity of the HM cells. The level of heparinase was low in the two variant cells. Attachment to liver sections was. however, more efficient with the HM than with the LM cells.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalPathobiology
Volume60
Issue number3
DOIs
StatePublished - 1992

Keywords

  • AKR lymphoma
  • Endothelial cells
  • Extracellular matrix
  • Malignancy variants
  • Tumor cell attachment

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