In 10 patients with mycosis fungoides (MF) who were in clinical remission following local treatment with nitrogen mustard, cell‐mediated immunity was investigated by means of tests for lymphocytes, forming rosettes in the peripheral blood, and the graft‐vs‐host reaction as well as intradermal skin tests. The effect of thymic humoral factor (THF) on T lymphocytes with impaired immunecompetence was also investigated. The results provided evidence of various kinds of damage to the immunologic system in most of the patients. Of the 10 patients, 4 had low percentages of T cells. Eight of the 10 had a graft‐vs.‐host reaction which was weak or negative, and in 4 of these, the administration of THF to the lymphocytes induced an improvement in immunereactivity. These results together with other recently reported data indicate that the determination of cell‐mediated immunity in patients with MF may be of prognostic importance. Those patients whose T lymphocytes respond to treatment with THF are probably the best candidates for immunotherapy. Cancer 46:41–44, 1980.
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|Published - 1 Jul 1980