Cell‐mediated immunity in patients with mycosis fungoides in clinical remission. Effect of thymic humoral factor on the immunocompetence of the lymphocytes

Michael David, Batya Shohat, Natan Trainin, Eleasar Feuerman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In 10 patients with mycosis fungoides (MF) who were in clinical remission following local treatment with nitrogen mustard, cell‐mediated immunity was investigated by means of tests for lymphocytes, forming rosettes in the peripheral blood, and the graft‐vs‐host reaction as well as intradermal skin tests. The effect of thymic humoral factor (THF) on T lymphocytes with impaired immunecompetence was also investigated. The results provided evidence of various kinds of damage to the immunologic system in most of the patients. Of the 10 patients, 4 had low percentages of T cells. Eight of the 10 had a graft‐vs.‐host reaction which was weak or negative, and in 4 of these, the administration of THF to the lymphocytes induced an improvement in immunereactivity. These results together with other recently reported data indicate that the determination of cell‐mediated immunity in patients with MF may be of prognostic importance. Those patients whose T lymphocytes respond to treatment with THF are probably the best candidates for immunotherapy. Cancer 46:41–44, 1980.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalCancer
Volume46
Issue number1
DOIs
StatePublished - 1 Jul 1980

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