TY - JOUR
T1 - Cell transplantation and genetic engineering
T2 - New approaches to cardiac pathology
AU - Leo, Jonathan
AU - Barbash, Israel M.
PY - 2003/10
Y1 - 2003/10
N2 - The remarkable progress in experimental cell transplantation, stem cell biology and genetic engineering promise new therapy and hopefully a cure for patients with end stage heart failure. Engineering of viable cardiac grafts with the potential to grow and remodel will provide new solutions to the serious problems of heart donor shortage. The ability to replace the injured heart muscle will have a dramatic influence on medicine, especially with the increasing number of patients with heart failure. This innovative research, now tested in human patients, still faces significant problems that need to be solved before it can be considered as an established therapeutic tool. The present review will focus on selected topics related to the promise and obstacles associated with cell transplantation, with and without genetic manipulation, for myocardial repair.
AB - The remarkable progress in experimental cell transplantation, stem cell biology and genetic engineering promise new therapy and hopefully a cure for patients with end stage heart failure. Engineering of viable cardiac grafts with the potential to grow and remodel will provide new solutions to the serious problems of heart donor shortage. The ability to replace the injured heart muscle will have a dramatic influence on medicine, especially with the increasing number of patients with heart failure. This innovative research, now tested in human patients, still faces significant problems that need to be solved before it can be considered as an established therapeutic tool. The present review will focus on selected topics related to the promise and obstacles associated with cell transplantation, with and without genetic manipulation, for myocardial repair.
KW - Cell
KW - Gene
KW - Heart failure
KW - Myocardial infarction
KW - Transplantation
UR - http://www.scopus.com/inward/record.url?scp=0142119212&partnerID=8YFLogxK
U2 - 10.1517/14712598.3.7.1023
DO - 10.1517/14712598.3.7.1023
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C2 - 14519068
AN - SCOPUS:0142119212
SN - 1471-2598
VL - 3
SP - 1023
EP - 1039
JO - Expert Opinion on Biological Therapy
JF - Expert Opinion on Biological Therapy
IS - 7
ER -