Cell transplantation and genetic engineering: New approaches to cardiac pathology

Jonathan Leo*, Israel M. Barbash

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The remarkable progress in experimental cell transplantation, stem cell biology and genetic engineering promise new therapy and hopefully a cure for patients with end stage heart failure. Engineering of viable cardiac grafts with the potential to grow and remodel will provide new solutions to the serious problems of heart donor shortage. The ability to replace the injured heart muscle will have a dramatic influence on medicine, especially with the increasing number of patients with heart failure. This innovative research, now tested in human patients, still faces significant problems that need to be solved before it can be considered as an established therapeutic tool. The present review will focus on selected topics related to the promise and obstacles associated with cell transplantation, with and without genetic manipulation, for myocardial repair.

Original languageEnglish
Pages (from-to)1023-1039
Number of pages17
JournalExpert Opinion on Biological Therapy
Volume3
Issue number7
DOIs
StatePublished - Oct 2003

Keywords

  • Cell
  • Gene
  • Heart failure
  • Myocardial infarction
  • Transplantation

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