Cell proliferation and antibody production in the secondary response in vitro towards a defined hapten

Rebeca Tarrab, A. Sulica, J. Haimovich, M. Sela*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cell proliferation and antibody production in a secondary response in vitro against the 2,4‐dinitrophenyl (DNP) group were followed by thymidine uptake, hemolytic plaque formation and inactivation of DNP‐bacteriophage T4. Thymidine uptake and plaque formation were both dependent on the amount of antigen used for stimulation of cells in vitro, whereas phage inactivation was not. The kinetics of the response as detected by the above three assays revealed that thymidine uptake preceded both plaque formation and antibody production.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalEuropean Journal of Immunology
Volume1
Issue number4
DOIs
StatePublished - 1971
Externally publishedYes

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