Cell-mediated immunity in patients with endometrial adenocarcinoma

Joseph Menczer, Jehoshua Dor, Yigal Soffer, David M. Serr

Research output: Contribution to journalArticlepeer-review

Abstract

The leukocyte migration inhibition test (LMIT) was used in eight patients with endometrial adenocarcinoma in order to evaluate the presence of a cell-mediated immune response to a soluble tumor extract. In three of four patients with tumor confined to the uterine cavity the LMIT was initially positive. Six to nine months after therapy a repeated LMIT was found to be negative. A negative LMIT was found in the other four patients with tumor extending beyond the uterine cavity. Negative assays were obtained when a homologous tumor extract with a positive autologous reaction was tested against leukocytes from two patients with extended disease. The possible significance of these findings is briefly discussed.

Original languageEnglish
Pages (from-to)223-228
Number of pages6
JournalGynecologic Oncology
Volume6
Issue number3
DOIs
StatePublished - Jun 1978

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