Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes

Ruth Levy; Esther Segal; Emanuel Eylan; Liliane Barr-Nea

doi:10.1007/BF00437023

Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes

Ruth Levy^*, Esther Segal, Emanuel Eylan, Liliane Barr-Nea

^*Corresponding author for this work

Clinical Microbiology and Immunology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.

Original language	English
Pages (from-to)	161-168
Number of pages	8
Journal	Mycopathologia
Volume	83
Issue number	3
DOIs	https://doi.org/10.1007/BF00437023
State	Published - Jan 1983

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title = "Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes",

abstract = "The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.",

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AB - The aim of the present study was to ascertain whether cell-mediated immunity (CMI) is induced in animals by vaccination with Candida albicans ribosomes. Delayed type hypersensitivity (DTH) was detected in vivo in ribosome-vaccinated mice and guinea pigs by the footpad swelling and skin tests, respectively. The observed DTH was similar to that induced by live C. albicans organisms. A lymphocyte transformation assay was used for in vitro detection of CMI. The tritiated thymidine incorporation assays revealed that spleen lymphocytes from mice immunized with C. albicans ribosomes were stimulated by the ribosomal antigen. The findings establish that C. albicans ribosomes are able to induce CMI in experimental animals.

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Cell-mediated immunity following experimental vaccinations with Candida albicans ribosomes

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