Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay

Martin J. Becker; Ruth Farkas; Mordechi Schneider; Ilana Drucker; Avraham Klajman

doi:10.1016/0090-1229(79)90141-7

Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay

Martin J. Becker, Ruth Farkas, Mordechi Schneider, Ilana Drucker, Avraham Klajman

Research output: Contribution to journal › Article › peer-review

Abstract

The functional status of T cells was examined with regard to age in normal humans. T-Cell cytotoxicity (CMC) as determined by a xenogeneic assay in vitro was found to be depressed (P < 0.02, Wilcoxon rank test) in the oldest group (Group 3: 60-70 years) compared to the two younger groups (Group 2: 50-59 years; Group 1: <50 years). CMC activity of Groups 1 and 2 did not differ significantly (P > 0.2). Both the optimal (P < 0.02) and suboptimal (P < 0.001) PHA responses were depressed in Group 3 compared to Groups 1 or 2. There was no significant difference between Concanavalin A responses or percentage B and percentage T cells among the three groups studied. These results are consistent with a selective decline in some T-cell functions with age in a human population.

Original language	English
Pages (from-to)	204-210
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(79)90141-7
State	Published - Oct 1979
Externally published	Yes

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title = "Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay",

abstract = "The functional status of T cells was examined with regard to age in normal humans. T-Cell cytotoxicity (CMC) as determined by a xenogeneic assay in vitro was found to be depressed (P < 0.02, Wilcoxon rank test) in the oldest group (Group 3: 60-70 years) compared to the two younger groups (Group 2: 50-59 years; Group 1: <50 years). CMC activity of Groups 1 and 2 did not differ significantly (P > 0.2). Both the optimal (P < 0.02) and suboptimal (P < 0.001) PHA responses were depressed in Group 3 compared to Groups 1 or 2. There was no significant difference between Concanavalin A responses or percentage B and percentage T cells among the three groups studied. These results are consistent with a selective decline in some T-cell functions with age in a human population.",

author = "Becker, {Martin J.} and Ruth Farkas and Mordechi Schneider and Ilana Drucker and Avraham Klajman",

note = "Funding Information: This work was supported in part by grants from the Chief Scientist{\textquoteright}s Office, Israel, and the Israel Cancer Society.",

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AU - Becker, Martin J.

AU - Farkas, Ruth

AU - Schneider, Mordechi

AU - Drucker, Ilana

AU - Klajman, Avraham

N1 - Funding Information: This work was supported in part by grants from the Chief Scientist’s Office, Israel, and the Israel Cancer Society.

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N2 - The functional status of T cells was examined with regard to age in normal humans. T-Cell cytotoxicity (CMC) as determined by a xenogeneic assay in vitro was found to be depressed (P < 0.02, Wilcoxon rank test) in the oldest group (Group 3: 60-70 years) compared to the two younger groups (Group 2: 50-59 years; Group 1: <50 years). CMC activity of Groups 1 and 2 did not differ significantly (P > 0.2). Both the optimal (P < 0.02) and suboptimal (P < 0.001) PHA responses were depressed in Group 3 compared to Groups 1 or 2. There was no significant difference between Concanavalin A responses or percentage B and percentage T cells among the three groups studied. These results are consistent with a selective decline in some T-cell functions with age in a human population.

AB - The functional status of T cells was examined with regard to age in normal humans. T-Cell cytotoxicity (CMC) as determined by a xenogeneic assay in vitro was found to be depressed (P < 0.02, Wilcoxon rank test) in the oldest group (Group 3: 60-70 years) compared to the two younger groups (Group 2: 50-59 years; Group 1: <50 years). CMC activity of Groups 1 and 2 did not differ significantly (P > 0.2). Both the optimal (P < 0.02) and suboptimal (P < 0.001) PHA responses were depressed in Group 3 compared to Groups 1 or 2. There was no significant difference between Concanavalin A responses or percentage B and percentage T cells among the three groups studied. These results are consistent with a selective decline in some T-cell functions with age in a human population.

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Cell-mediated cytotoxicity in humans: Age-related decline as measured by a xenogeneic assay

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