Cell-Based Therapies for the Treatment of Fractures

Joseph Borrelli, Gregory J. Della Rocca, Prism Schneider, Hans Christoph Pape, Paolo Cinelli, Yoram Weil, Amal Khoury, Meir Liebergall, Tracy Watson

Research output: Contribution to journalArticlepeer-review

Abstract

Ongoing studies investigating fracture healing have uncovered and allowed investigators to gain a better understanding of where the variety of cells, which participate in this process, originate, and how they communicate as well as how they can be enhanced to successfully heal a fracture when the process has slowed or failed completely. This brief review will highlight some of the recent findings regarding the role the immune system in fracture healing and how these cells communicate with each other during the healing process. In addition, two 2 methods that have recently been shown to be promising techniques in supporting fracture when it stalls or reversing the process, when the fracture has failed to heal, will also be described.

Original languageEnglish
Pages (from-to)S39-S43
JournalJournal of Orthopaedic Trauma
Volume33
DOIs
StatePublished - 1 Jun 2019
Externally publishedYes

Keywords

  • Angiogenesis
  • Bone marrow aspirate
  • Extracellular vesicles
  • Mesenchymal stem cells
  • Osteoimmunology

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