TY - JOUR
T1 - Cell-Based Therapies for the Treatment of Fractures
AU - Borrelli, Joseph
AU - Della Rocca, Gregory J.
AU - Schneider, Prism
AU - Pape, Hans Christoph
AU - Cinelli, Paolo
AU - Weil, Yoram
AU - Khoury, Amal
AU - Liebergall, Meir
AU - Watson, Tracy
N1 - Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Ongoing studies investigating fracture healing have uncovered and allowed investigators to gain a better understanding of where the variety of cells, which participate in this process, originate, and how they communicate as well as how they can be enhanced to successfully heal a fracture when the process has slowed or failed completely. This brief review will highlight some of the recent findings regarding the role the immune system in fracture healing and how these cells communicate with each other during the healing process. In addition, two 2 methods that have recently been shown to be promising techniques in supporting fracture when it stalls or reversing the process, when the fracture has failed to heal, will also be described.
AB - Ongoing studies investigating fracture healing have uncovered and allowed investigators to gain a better understanding of where the variety of cells, which participate in this process, originate, and how they communicate as well as how they can be enhanced to successfully heal a fracture when the process has slowed or failed completely. This brief review will highlight some of the recent findings regarding the role the immune system in fracture healing and how these cells communicate with each other during the healing process. In addition, two 2 methods that have recently been shown to be promising techniques in supporting fracture when it stalls or reversing the process, when the fracture has failed to heal, will also be described.
KW - Angiogenesis
KW - Bone marrow aspirate
KW - Extracellular vesicles
KW - Mesenchymal stem cells
KW - Osteoimmunology
UR - http://www.scopus.com/inward/record.url?scp=85066061618&partnerID=8YFLogxK
U2 - 10.1097/BOT.0000000000001478
DO - 10.1097/BOT.0000000000001478
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C2 - 31083148
AN - SCOPUS:85066061618
SN - 0890-5339
VL - 33
SP - S39-S43
JO - Journal of Orthopaedic Trauma
JF - Journal of Orthopaedic Trauma
ER -