Cell and gene therapy in alzheimer's disease

Micaela Johanna Glat, Daniel Offen

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer's disease (AD) is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-β and hyperphosphorylated tau, and by neuronal and synaptic loss. Although some drugs have been shown to slow the progression of the disease, at present no treatment has been developed that can stop or reverse the progression of the pathology. Recently, new therapeutic strategies have been proposed for the treatment of the disease. Among these, the development of stem cells and gene-modified cells is an especially promising therapeutic approach for AD. In this review we highlight the experimental and preclinical studies that have been focused on stem cell-based and gene-modified cell-based uses as potential therapies for AD. The potential clinical applications are also discussed.

Original languageEnglish
Pages (from-to)1490-1496
Number of pages7
JournalStem Cells and Development
Volume22
Issue number10
DOIs
StatePublished - 15 May 2013

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