TY - JOUR
T1 - Cell and gene therapy in alzheimer's disease
AU - Glat, Micaela Johanna
AU - Offen, Daniel
PY - 2013/5/15
Y1 - 2013/5/15
N2 - Alzheimer's disease (AD) is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-β and hyperphosphorylated tau, and by neuronal and synaptic loss. Although some drugs have been shown to slow the progression of the disease, at present no treatment has been developed that can stop or reverse the progression of the pathology. Recently, new therapeutic strategies have been proposed for the treatment of the disease. Among these, the development of stem cells and gene-modified cells is an especially promising therapeutic approach for AD. In this review we highlight the experimental and preclinical studies that have been focused on stem cell-based and gene-modified cell-based uses as potential therapies for AD. The potential clinical applications are also discussed.
AB - Alzheimer's disease (AD) is a progressive neurological disorder characterized by the aggregation of two proteins, amyloid-β and hyperphosphorylated tau, and by neuronal and synaptic loss. Although some drugs have been shown to slow the progression of the disease, at present no treatment has been developed that can stop or reverse the progression of the pathology. Recently, new therapeutic strategies have been proposed for the treatment of the disease. Among these, the development of stem cells and gene-modified cells is an especially promising therapeutic approach for AD. In this review we highlight the experimental and preclinical studies that have been focused on stem cell-based and gene-modified cell-based uses as potential therapies for AD. The potential clinical applications are also discussed.
UR - http://www.scopus.com/inward/record.url?scp=84877316680&partnerID=8YFLogxK
U2 - 10.1089/scd.2012.0633
DO - 10.1089/scd.2012.0633
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
AN - SCOPUS:84877316680
SN - 1547-3287
VL - 22
SP - 1490
EP - 1496
JO - Stem Cells and Development
JF - Stem Cells and Development
IS - 10
ER -