Celecoxib and curcumin additively inhibit the growth of colorectal cancer in a rat model

Baruch Shpitz, Nis Giladi, Eyal Sagiv, Shahar Lev-Ari, Eliezer Liberman, Diana Kazanov, Nadir Arber

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Multiple studies have indicated that specific COX-2 inhibitors may prevent CRC. However, the long-term use of COX-2 inhibitors is not toxicity-free and may be limited due to its cardiovascular side effects. The present study was carried out to examine the chemopreventive effects of celecoxib and curcumin alone and in combination using the 1,2-dimethylhydrazine (DMH) rat model. Methods: Male rats were injected with DMH and randomly divided into four groups that consumed one of the following diets: (a) AIN-076 control diet; (b) AIN-076/curcumin (0.6%); (c) AIN-076/celecoxib (0.16%), or (d) AIN-076/celecoxib (0.16%) and curcumin (0.6%). Aberrant crypt foci (ACF) were identified by intensive staining with methylene blue in comparison to the surrounding normal crypts. Results: The average number of ACF per rat colon was 64.2 ± 3 in the control group, 39 ± 5 and 47 ± 10 for the curcumin- and celecoxib-treated group, respectively, and 24.5 ± 6 in the group that had received both agents. Conclusions: In vivo, curcumin augments the growth inhibitory effect of celecoxib. This may be clinically important as this dose of celecoxib can be achieved in human serum following standard anti-inflammatory dosing of 100 mg.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalDigestion
Volume74
Issue number3-4
DOIs
StatePublished - Apr 2007

Keywords

  • Celecoxib
  • Chemoprevention
  • Colorectal cancer
  • Curcumin
  • Cyclooxygenase-2

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