CEACAM1-Mediated Inhibition of Virus Production

Alon Vitenshtein, Yiska Weisblum, Sebastian Hauka, Anne Halenius, Esther Oiknine-Djian, Pinchas Tsukerman, Yoav Bauman, Yotam Bar-On, Noam Stern-Ginossar, Jonatan Enk, Rona Ortenberg, Julie Tai, Gal Markel, Richard S. Blumberg, Hartmut Hengel, Stipan Jonjic, Dana G. Wolf, Heiko Adler, Robert Kammerer, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.

Original languageEnglish
Pages (from-to)2331-2339
Number of pages9
JournalCell Reports
Issue number11
StatePublished - 14 Jun 2016


FundersFunder number
GIF Foundation
Helmholtz Israel275/13
Samueli Institute Brain Mind & Healing Center
National Institute of Diabetes and Digestive and Kidney DiseasesP30DK034854
Medical Research and Materiel Command
Israel Cancer Research Fund
U.S. Army Medical Research Acquisition Activity
European Research Council320473-BacNK
Israel Science Foundation
Seventh Framework ProgrammeFP/2007-2013, 316655
Ministry of Health, State of Israel10998


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