TY - JOUR
T1 - CEACAM1 in malignant melanoma
T2 - A diagnostic and therapeutic target
AU - Sapoznik, S.
AU - Ortenberg, R.
AU - Schachter, J.
AU - Markel, G.
PY - 2012/1
Y1 - 2012/1
N2 - CEACAM1 adhesion molecule is broadly expressed, participates in pivotal cellular and immunological processes and is involved in cancer. Originally identified as a tumor suppressor, it is now known that in several cancers, including malignant melanoma, CEACAM1 expression correlates with tumor progression and poor survival. Here we review the findings connecting CEACAM1 to malignant melanoma, encompassing in-vitro, in-vivo and patients-derived data. A CEACAM1-mediated mechanism used by melanoma cells to evade immune attack is described in detail. Finally, the potential value of CEACAM1 as a melanoma biomarker and therapeutic target is being discussed.
AB - CEACAM1 adhesion molecule is broadly expressed, participates in pivotal cellular and immunological processes and is involved in cancer. Originally identified as a tumor suppressor, it is now known that in several cancers, including malignant melanoma, CEACAM1 expression correlates with tumor progression and poor survival. Here we review the findings connecting CEACAM1 to malignant melanoma, encompassing in-vitro, in-vivo and patients-derived data. A CEACAM1-mediated mechanism used by melanoma cells to evade immune attack is described in detail. Finally, the potential value of CEACAM1 as a melanoma biomarker and therapeutic target is being discussed.
KW - Biomarker
KW - CEACAM1
KW - Cancer
KW - Immunotherapy
KW - Lymphocytes
KW - Melanoma
UR - http://www.scopus.com/inward/record.url?scp=84855837412&partnerID=8YFLogxK
U2 - 10.2174/156802612798919259
DO - 10.2174/156802612798919259
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C2 - 22196267
AN - SCOPUS:84855837412
SN - 1568-0266
VL - 12
SP - 3
EP - 10
JO - Current Topics in Medicinal Chemistry
JF - Current Topics in Medicinal Chemistry
IS - 1
ER -
