CD5+ B cells and naturally occurring autoantibodies in cancer patients

R. STEIN, I. P. WITZ, J. OVADlA, D. M. GOLDENBERG, I. YRON

Research output: Contribution to journalArticlepeer-review

Abstract

We have determined the percentage of CD5+ B lymphocytes in the peripheral blood of cancer patients and healthy controls, using antibodies directed at the CDS and CD 19 (pan‐B) markers. The frequencies of CD5+ B cells, expressed as a percentage of total B cells, ranged from 14.3 to 57.5% in the controls and from 14.8 to 82.8% in the patient population. One‐third of the cancer patients had frequencies > 2 s.d. above the mean of the control population. The CD5+ B cell fraction expressed as a percentage of total lymphocytes was also significantly elevated in this group of cancer patients. These results suggest that the CD5+ B cell compartment may be affected by the malignant process or by the therapy modality employed. The plasma levels of several naturally occurring autoantibodies, the products of the CD5+ B cells, were also assessed in cancer patients and controls. No significant differences were observed when reactivity to several autoantigens was measured. These included nuclear components and phospholipids.

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalClinical and Experimental Immunology
Volume85
Issue number3
DOIs
StatePublished - Sep 1991

Keywords

  • CD5 B cells
  • autoantibodies
  • cancer

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