CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

Zvi Grossman; Martin Meier-Schellersheim; Ana E. Sousa; Rui M.M. Victorino; William E. Paul

doi:10.1038/nm0402-319

CD4⁺ T-cell depletion in HIV infection: Are we closer to understanding the cause?

Zvi Grossman, Martin Meier-Schellersheim, Ana E. Sousa, Rui M.M. Victorino, William E. Paul

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

383 Scopus citations

Abstract

Is CD4⁺ cell depletion due to rapid elimination by HIV and failure of the immune system to replace these cells at the required rate? Increasing evidence suggests that this is not the case, and that infection-induced immune activation drives both viral replication and CD4⁺ cell depletion.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Nature Medicine
Volume	8
Issue number	4
DOIs	https://doi.org/10.1038/nm0402-319
State	Published - Apr 2002

Funding

Funders	Funder number
National Institute of Allergy and Infectious Diseases	Z01AI000926

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/nm0402-319

Cite this

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