CD1a-positive dendritic cell density predicts disease-free survival in papillary thyroid carcinoma

Ohad Hilly, Lea Rath-Wolfson, Rumelia Koren, Aviram Mizrachi, Yaniv Hamzany, Gideon Bachar, Thomas Shpitzer

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Dendritic cells are common in inflammatory processes and in papillary thyroid carcinoma (PTC). Previous studies of the predictive value of S100-positive dendritic cell density for PTC outcome yielded inconsistent results. This study investigated the association of dendritic cell density and PTC recurrence based on CD1a expression. Methods: Representative slides from 56 consecutive specimens of PTC were immunostained with anti-CD1a antibodies, and dendritic cell density was analyzed by disease-free survival. Results: Dendritic cells were abundant in the tumoral tissue and sparse in the normal peritumoral tissue. Peritumoral dendritic cell density >1.1 cells/HPF was inversely associated with the risk of recurrence. Similar results were obtained with tumoral dendritic cell density (>12 cells/HPF), although the statistical significance was marginal. Conclusions: High CD1a-positive dendritic cell density is associated with improved disease-free survival in PTC. The specificity of anti-CD1a immunostain for activated dendritic cells may explain the better outcome prediction in this study than in studies using S100 protein.

Original languageEnglish
Pages (from-to)652-656
Number of pages5
JournalPathology Research and Practice
Volume211
Issue number9
DOIs
StatePublished - 1 Sep 2015

Keywords

  • CD1a
  • Dendritic cells
  • Disease free survival
  • Papillary thyroid carcinoma

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