@article{de6c43bc40794914adc71bfa8e8057e7,
title = "CD1a-positive dendritic cell density predicts disease-free survival in papillary thyroid carcinoma",
abstract = "Objectives: Dendritic cells are common in inflammatory processes and in papillary thyroid carcinoma (PTC). Previous studies of the predictive value of S100-positive dendritic cell density for PTC outcome yielded inconsistent results. This study investigated the association of dendritic cell density and PTC recurrence based on CD1a expression. Methods: Representative slides from 56 consecutive specimens of PTC were immunostained with anti-CD1a antibodies, and dendritic cell density was analyzed by disease-free survival. Results: Dendritic cells were abundant in the tumoral tissue and sparse in the normal peritumoral tissue. Peritumoral dendritic cell density >1.1 cells/HPF was inversely associated with the risk of recurrence. Similar results were obtained with tumoral dendritic cell density (>12 cells/HPF), although the statistical significance was marginal. Conclusions: High CD1a-positive dendritic cell density is associated with improved disease-free survival in PTC. The specificity of anti-CD1a immunostain for activated dendritic cells may explain the better outcome prediction in this study than in studies using S100 protein.",
keywords = "CD1a, Dendritic cells, Disease free survival, Papillary thyroid carcinoma",
author = "Ohad Hilly and Lea Rath-Wolfson and Rumelia Koren and Aviram Mizrachi and Yaniv Hamzany and Gideon Bachar and Thomas Shpitzer",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier GmbH.",
year = "2015",
month = sep,
day = "1",
doi = "10.1016/j.prp.2015.05.009",
language = "אנגלית",
volume = "211",
pages = "652--656",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Elsevier GmbH",
number = "9",
}