@article{a0267fa2ebb949cc94e85adedad637b4,
title = "CCR5 Is a Therapeutic Target for Recovery after Stroke and Traumatic Brain Injury",
abstract = "We tested a newly described molecular memory system, CCR5 signaling, for its role in recovery after stroke and traumatic brain injury (TBI). CCR5 is uniquely expressed in cortical neurons after stroke. Post-stroke neuronal knockdown of CCR5 in pre-motor cortex leads to early recovery of motor control. Recovery is associated with preservation of dendritic spines, new patterns of cortical projections to contralateral pre-motor cortex, and upregulation of CREB and DLK signaling. Administration of a clinically utilized FDA-approved CCR5 antagonist, devised for HIV treatment, produces similar effects on motor recovery post stroke and cognitive decline post TBI. Finally, in a large clinical cohort of stroke patients, carriers for a naturally occurring loss-of-function mutation in CCR5 (CCR5-Δ32) exhibited greater recovery of neurological impairments and cognitive function. In summary, CCR5 is a translational target for neural repair in stroke and TBI and the first reported gene associated with enhanced recovery in human stroke.",
keywords = "MOCA, NIHSS, astrocyte, axon, axonal sprouting, dendritic spine, microglia, motor, premotor",
author = "Joy, {Mary T.} and {Ben Assayag}, Einor and Dalia Shabashov-Stone and Sigal Liraz-Zaltsman and Jose Mazzitelli and Marcela Arenas and Nora Abduljawad and Efrat Kliper and Korczyn, {Amos D.} and Thareja, {Nikita S.} and Kesner, {Efrat L.} and Miou Zhou and Shan Huang and Silva, {Tawnie K.} and Noomi Katz and Bornstein, {Natan M.} and Silva, {Alcino J.} and Esther Shohami and Carmichael, {S. Thomas}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = feb,
day = "21",
doi = "10.1016/j.cell.2019.01.044",
language = "אנגלית",
volume = "176",
pages = "1143--1157.e13",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "5",
}