Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

Catharina Busch; Matias Iglicki; Mali Okada; Pierre Henry Gabrielle; Shai Cohen; Miriana Mariussi; Atchara Amphornphruet; Zafer Cebeci; Voraporn Chaikitmongkol; Aude Couturier; Samantha Fraser-Bell; Adrian T. Fung; Danilo Iannetta; Liga Radecka; Inês Laíns; Tiago M. Rodrigues; Marco Lupidi; Małgorzata Ozimek; Anna Sala-Puigdollers; Matus Rehak; Anat Loewenstein; Dinah Zur

doi:10.1159/000496942

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

Catharina Busch, Matias Iglicki, Mali Okada, Pierre Henry Gabrielle, Shai Cohen, Miriana Mariussi, Atchara Amphornphruet, Zafer Cebeci, Voraporn Chaikitmongkol, Aude Couturier, Samantha Fraser-Bell, Adrian T. Fung, Danilo Iannetta, Liga Radecka, Inês Laíns, Tiago M. Rodrigues, Marco Lupidi, Małgorzata Ozimek, Anna Sala-Puigdollers, Matus RehakAnat Loewenstein, Dinah Zur

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Abstract

Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

Original language	English
Pages (from-to)	211-219
Number of pages	9
Journal	Ophthalmologica
Volume	241
Issue number	4
DOIs	https://doi.org/10.1159/000496942
State	Published - 1 Apr 2019

Keywords

Endophthalmitis
Intravitreal injection
Vascular endothelial growth factor

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10.1159/000496942

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Busch, C., Iglicki, M., Okada, M., Gabrielle, P. H., Cohen, S., Mariussi, M., Amphornphruet, A., Cebeci, Z., Chaikitmongkol, V., Couturier, A., Fraser-Bell, S., Fung, A. T., Iannetta, D., Radecka, L., Laíns, I., Rodrigues, T. M., Lupidi, M., Ozimek, M., Sala-Puigdollers, A., ... Zur, D. (2019). Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study. Ophthalmologica, 241(4), 211-219. https://doi.org/10.1159/000496942

Busch, Catharina ; Iglicki, Matias ; Okada, Mali ; Gabrielle, Pierre Henry ; Cohen, Shai ; Mariussi, Miriana ; Amphornphruet, Atchara ; Cebeci, Zafer ; Chaikitmongkol, Voraporn ; Couturier, Aude ; Fraser-Bell, Samantha ; Fung, Adrian T. ; Iannetta, Danilo ; Radecka, Liga ; Laíns, Inês ; Rodrigues, Tiago M. ; Lupidi, Marco ; Ozimek, Małgorzata ; Sala-Puigdollers, Anna ; Rehak, Matus ; Loewenstein, Anat ; Zur, Dinah. / Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection : An International Multicenter Study. In: Ophthalmologica. 2019 ; Vol. 241, No. 4. pp. 211-219.

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title = "Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study",

abstract = "Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.",

keywords = "Endophthalmitis, Intravitreal injection, Vascular endothelial growth factor",

author = "Catharina Busch and Matias Iglicki and Mali Okada and Gabrielle, {Pierre Henry} and Shai Cohen and Miriana Mariussi and Atchara Amphornphruet and Zafer Cebeci and Voraporn Chaikitmongkol and Aude Couturier and Samantha Fraser-Bell and Fung, {Adrian T.} and Danilo Iannetta and Liga Radecka and In{\^e}s La{\'i}ns and Rodrigues, {Tiago M.} and Marco Lupidi and Ma{\l}gorzata Ozimek and Anna Sala-Puigdollers and Matus Rehak and Anat Loewenstein and Dinah Zur",

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doi = "10.1159/000496942",

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Busch, C, Iglicki, M, Okada, M, Gabrielle, PH, Cohen, S, Mariussi, M, Amphornphruet, A, Cebeci, Z, Chaikitmongkol, V, Couturier, A, Fraser-Bell, S, Fung, AT, Iannetta, D, Radecka, L, Laíns, I, Rodrigues, TM, Lupidi, M, Ozimek, M, Sala-Puigdollers, A, Rehak, M, Loewenstein, A & Zur, D 2019, 'Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study', Ophthalmologica, vol. 241, no. 4, pp. 211-219. https://doi.org/10.1159/000496942

Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection : An International Multicenter Study. / Busch, Catharina; Iglicki, Matias; Okada, Mali; Gabrielle, Pierre Henry; Cohen, Shai; Mariussi, Miriana; Amphornphruet, Atchara; Cebeci, Zafer; Chaikitmongkol, Voraporn; Couturier, Aude; Fraser-Bell, Samantha; Fung, Adrian T.; Iannetta, Danilo; Radecka, Liga; Laíns, Inês; Rodrigues, Tiago M.; Lupidi, Marco; Ozimek, Małgorzata; Sala-Puigdollers, Anna; Rehak, Matus; Loewenstein, Anat; Zur, Dinah.

In: Ophthalmologica, Vol. 241, No. 4, 01.04.2019, p. 211-219.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection

T2 - An International Multicenter Study

AU - Busch, Catharina

AU - Iglicki, Matias

AU - Okada, Mali

AU - Gabrielle, Pierre Henry

AU - Cohen, Shai

AU - Mariussi, Miriana

AU - Amphornphruet, Atchara

AU - Cebeci, Zafer

AU - Chaikitmongkol, Voraporn

AU - Couturier, Aude

AU - Fraser-Bell, Samantha

AU - Fung, Adrian T.

AU - Iannetta, Danilo

AU - Radecka, Liga

AU - Laíns, Inês

AU - Rodrigues, Tiago M.

AU - Lupidi, Marco

AU - Ozimek, Małgorzata

AU - Sala-Puigdollers, Anna

AU - Rehak, Matus

AU - Loewenstein, Anat

AU - Zur, Dinah

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

AB - Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.

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KW - Intravitreal injection

KW - Vascular endothelial growth factor

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Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study

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Keywords

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