TY - JOUR
T1 - Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection
T2 - An International Multicenter Study
AU - Busch, Catharina
AU - Iglicki, Matias
AU - Okada, Mali
AU - Gabrielle, Pierre Henry
AU - Cohen, Shai
AU - Mariussi, Miriana
AU - Amphornphruet, Atchara
AU - Cebeci, Zafer
AU - Chaikitmongkol, Voraporn
AU - Couturier, Aude
AU - Fraser-Bell, Samantha
AU - Fung, Adrian T.
AU - Iannetta, Danilo
AU - Radecka, Liga
AU - Laíns, Inês
AU - Rodrigues, Tiago M.
AU - Lupidi, Marco
AU - Ozimek, Małgorzata
AU - Sala-Puigdollers, Anna
AU - Rehak, Matus
AU - Loewenstein, Anat
AU - Zur, Dinah
N1 - Publisher Copyright:
© 2019 S. Karger AG, Basel.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.
AB - Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers. Results: Eighty-three cases with 87 identified pathogens were included. Coagulase-negative staphylococci (59%) and viridans streptococci (15%) were the most frequent pathogens found. The use of postoperative antibiotics and performance of injections in an operating room setting significantly reduced the rate of streptococcus-induced endophthalmitis cases (p = 0.01 for both). Conclusion: We found a statistically significant lower rate of postinjectional local antibiotic therapy and operating room-based procedures among the streptococcus-induced cases compared to cases caused by other organisms.
KW - Endophthalmitis
KW - Intravitreal injection
KW - Vascular endothelial growth factor
UR - http://www.scopus.com/inward/record.url?scp=85063466808&partnerID=8YFLogxK
U2 - 10.1159/000496942
DO - 10.1159/000496942
M3 - מאמר
C2 - 30889590
AN - SCOPUS:85063466808
VL - 241
SP - 211
EP - 219
JO - Ophthalmologica
JF - Ophthalmologica
SN - 0030-3755
IS - 4
ER -