TY - JOUR
T1 - Cation/proton antiporters
T2 - novel structure-driven pharmaceutical opportunities
AU - Masrati, Gal
AU - Kessel, Amit
AU - Ben-Tal, Nir
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/5
Y1 - 2023/5
N2 - Cation/proton antiporters (CPAs) regulate cells’ salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.
AB - Cation/proton antiporters (CPAs) regulate cells’ salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.
KW - cation/proton antiporters
KW - computational biology
KW - pharmacology
UR - http://www.scopus.com/inward/record.url?scp=85150372302&partnerID=8YFLogxK
U2 - 10.1016/j.tips.2023.02.006
DO - 10.1016/j.tips.2023.02.006
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C2 - 36934025
AN - SCOPUS:85150372302
SN - 0165-6147
VL - 44
SP - 258
EP - 262
JO - Trends in Pharmacological Sciences
JF - Trends in Pharmacological Sciences
IS - 5
ER -