Cationic Pillararenes Potently Inhibit Biofilm Formation without Affecting Bacterial Growth and Viability

Roymon Joseph, Alissa Naugolny, Mark Feldman, Ido M. Herzog, Micha Fridman, Yoram Cohen

Research output: Contribution to journalArticlepeer-review

Abstract

It is estimated that up to 80% of bacterial infections are accompanied by biofilm formation. Since bacteria in biofilms are less susceptible to antibiotics than are bacteria in the planktonic state, biofilm-associated infections pose a major health threat, and there is a pressing need for antibiofilm agents. Here we report that water-soluble cationic pillararenes differing in the quaternary ammonium groups efficiently inhibited the formation of biofilms by clinically important Gram-positive pathogens. Biofilm inhibition did not result from antimicrobial activity; thus, the compounds should not inhibit growth of natural bacterial flora. Moreover, none of the cationic pillararenes caused detectable membrane damage to red blood cells or toxicity to human cells in culture. The results indicate that cationic pillararenes have potential for use in medical applications in which biofilm formation is a problem.

Original languageEnglish
Pages (from-to)754-757
Number of pages4
JournalJournal of the American Chemical Society
Volume138
Issue number3
DOIs
StatePublished - 27 Jan 2016

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