Catalytic oxidation of hydrazo derivatives promoted by a TiCl 3/HBr system

Eyal Drug, Michael Gozin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Through a novel catalytic process of general synthetic interest, hydrazo compounds were efficiently and selectively converted into corresponding azo derivatives. The proposed mechanism of this process comprises two separate and distinctive catalytic cycles, linked together by radical species. The first cycle includes formation of a hydroxy radical, generated by Ti(III) single-electron reduction of H2O2. In the second cycle, the hydroxy radical oxidizes HBr into hypobromous acid, which in turn is reduced back to HBr and water by a hydrazo substrate.

Original languageEnglish
Pages (from-to)13784-13785
Number of pages2
JournalJournal of the American Chemical Society
Issue number45
StatePublished - 14 Nov 2007


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