Catalepsy induced by carbachol microinjected into the pontine reticular formation of rats

Zeev Elazar, Milka Paz

Research output: Contribution to journalArticlepeer-review

Abstract

Rats were implanted stereotaxically with permanent guide tubes aimed at the pontine reticular formation. Carbachol was microinjected in the awake, freely moving rats. Catalepsy was evaluated with the horizontal bar test. Intense and long-lasting, dose-dependent catalepsy was observed following microinjections of 2-8 μg of carbachol. Pretreatment with intrapeitoneally administered scopolamine significantly reduced the cataleptogenic effect of carbachol. These results show that the pontine reticular formation is part of the neuroanatomical substrate of catalepsy induced by cholinergic drugs.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalNeuroscience Letters
Volume115
Issue number2-3
DOIs
StatePublished - 31 Jul 1990

Keywords

  • Carbachol
  • Catalepsy
  • Pontine reticular formation
  • Rat

Fingerprint

Dive into the research topics of 'Catalepsy induced by carbachol microinjected into the pontine reticular formation of rats'. Together they form a unique fingerprint.

Cite this