Cat scratch disease: The rare role of Afipia felis

Michael Giladi*, Boaz Avidor, Yehudith Kletter, Suzy Abulafia, Leonard N. Slater, David F. Welch, Don J. Brenner, Arnold G. Steigerwalt, Anne M. Whitney, Moshe Ephros

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Since its isolation in 1988, Afipia felis has been associated with cat scratch disease (CSD) in only one report and its role in CSD has been questioned. We have cultured A. felis from a lymph node of a patient with CSD. 16S rRNA gene sequencing, DNA relatedness studies, fatty acid analysis, and PCR of the A. felis ferredoxin gene showed that the isolate is identical to the previously reported A. felis isolate. To determine the role of A felis in CSD, PCR Of the 16S rRNA gene followed by hybridizations with specific probes were performed with lymph node specimens from CSD patients. All 32 specimens tested positive for Bartonella henselae and negative for A. felis. We conclude that A. felis is a rare cause of CSD. Diagnostic tests not conducive to the identification of A. felis might cause the diagnosis of CSD due to A. felis to be missed.

Original languageEnglish
Pages (from-to)2499-2502
Number of pages4
JournalJournal of Clinical Microbiology
Issue number9
StatePublished - Sep 1998
Externally publishedYes


Dive into the research topics of 'Cat scratch disease: The rare role of Afipia felis'. Together they form a unique fingerprint.

Cite this