Ca2+-dependent splicing of neurexin IIα

G. Rozic-Kotliroff, N. Zisapel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Neurexins are synaptic adhesion proteins encoded by 3 genes (NRXN1, NRXN2, and NRXN3) each transcribed from 2 promoters to yield longer (α) and shorter (β) forms. The primary gene transcripts undergo extensive alternative splicing leading to products that may differ in synaptic coupling properties. Here we show that depolarization of neurons modulates splicing of NRXN2α, particularly at splice sites 1 and 3. Furthermore, we demonstrate that exclusion of exon 11 at splice site 3 is calcium-dependent. These data indicate neuronal activity-dependent splicing of NRXN2α. This dynamic process may be important for maintenance of mature neuronal circuits.

Original languageEnglish
Pages (from-to)226-230
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - 5 Jan 2007


  • Calcium
  • Depolarization
  • Neurexin
  • Splicing
  • mRNA


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