Case Series

Katherine E. Travis, Yael Leitner, Michal Ben-Shachar, Kristen W. Yeom, Heidi M. Feldman

Research output: Contribution to journalArticlepeer-review

Abstract

This case series assesses white matter microstructure of the cerebellar peduncles in 4 adolescents born preterm with enlarged ventricles and reduced white matter volume in the cerebrum but no apparent injury to the cerebellum. Subjects (ages 12-17 years, gestational age 26-32 weeks, birth weight 825-2211 g) were compared to a normative sample of 19 full-term controls (9-17 years, mean gestational age 39 weeks, mean birth weight 3154 g). Tract profiles for each of the cerebellar peduncles were generated by calculating fractional anisotropy at 30 points along the central portion of each tract. One or more case subjects exhibited higher fractional anisotropy beyond the 90th percentile in the inferior, middle, and superior cerebellar peduncles. Findings demonstrate that differences in cerebellar white matter microstructure can be detected in the absence of macrostructural cerebellar abnormalities.

Original languageEnglish
Pages (from-to)321-327
Number of pages7
JournalJournal of Child Neurology
Volume31
Issue number3
DOIs
StatePublished - 1 Mar 2016

Keywords

  • cerebellum
  • diffusion MRI
  • preterm
  • tractography
  • white matter

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