Carriage of mediterranean fever (MEFV) mutations in patients with postpericardiotomy syndrome (PPS)

Ido David Dechtman, Chagai Grossman, Yael Shinar, Rinat Cohen, Eyal Nachum, Ehud Raanani, Avi Livneh, Ilan Ben-Zvi

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Postpericardiotomy syndrome (PPS) is characterized by pleuro-pericardial inflammation, which occurs in patients undergoing surgical procedures involving the pleura, pericardium, or both. The syndrome is considered to be immune mediated. However, its pathogenesis is not fully understood. It has previously been demonstrated that the Mediterranean Fever (MEFV) gene, which is associated with familial Mediterranean fever (FMF), has a role in the activation and expression of several inflammatory diseases. Objectives: To investigate whether carriage of the MEFV mutation may precipitate PPS or affect its phenotype. Methods: The study population included 45 patients who underwent cardiac surgery and developed PPS. The control group was comprised of 41 patients who did not develop PPS. Clinical and demographic data was collected. The severity of PPS was evaluated. Genetic analysis to determine the carriage of one the three most common MEFV gene mutations (M694V, V726A, E148Q) was performed. The carriage rate of MEFV mutations in patients with and without PPS was compared. Association between MEFV mutation carriage and severity of PPS was evaluated. Results: The rate of mutation carriage in the MEFV gene was similar in patients with and without PPS (15.6% in the study groups vs. 29.3% in the control group, P = 0.1937). The rate of mutation carriage in the MEFV gene was significantly lower among patients with severe PPS as compared to patients with mild-moderate PPS (4.8% vs. 25%, P < 0.05). Conclusions: Carriage of mutations in the MEFV gene is not associated with development of PPS; however, it may affect PPS severity.

Original languageEnglish
Pages (from-to)562-565
Number of pages4
JournalIsrael Medical Association Journal
Volume19
Issue number9
StatePublished - Sep 2017

Keywords

  • Ethnic origin
  • Familial Mediterranean fever (FMF)
  • Mediterranean FeVer (MEFV) gene mutations
  • Postpericardiotomy syndrome (PPS)

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