TY - JOUR
T1 - Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk
AU - Dubinsky, Vadim
AU - Dotan, Iris
AU - Gophna, Uri
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.
AB - Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.
UR - http://www.scopus.com/inward/record.url?scp=85085958896&partnerID=8YFLogxK
U2 - 10.1016/j.tim.2020.05.015
DO - 10.1016/j.tim.2020.05.015
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C2 - 32507544
AN - SCOPUS:85085958896
SN - 0966-842X
VL - 28
SP - 874
EP - 876
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 11
ER -