TY - JOUR
T1 - Carotid artery intima-media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis
AU - Sherer, Yaniv
AU - Pagnoux, Christian
AU - Chironi, Gilles
AU - Simon, Alain
AU - Guillevin, Loïc
AU - Mouthon, Luc
AU - Gilburd, Boris
AU - Shoenfeld, Yehuda
N1 - Funding Information:
Acknowledgments This study was supported in part by the Federico Foundation (to Y Sherer and Y Shoenfeld).
PY - 2008/9
Y1 - 2008/9
N2 - In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima-media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.
AB - In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima-media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.
KW - Autoantibody
KW - Heat shock protein-60
KW - Heat shock protein-65
KW - Oxidized low-density lipoprotein
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=49649096847&partnerID=8YFLogxK
U2 - 10.1007/s00296-008-0587-7
DO - 10.1007/s00296-008-0587-7
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AN - SCOPUS:49649096847
SN - 0172-8172
VL - 28
SP - 1099
EP - 1103
JO - Rheumatology International
JF - Rheumatology International
IS - 11
ER -
