TY - JOUR
T1 - Cardiovascular Risk Factors and Physical Fitness Among Subjects with Asymptomatic Colonic Diverticulosis
AU - Ukashi, Offir
AU - Pflantzer, Barak
AU - Barash, Yiftach
AU - Klang, Eyal
AU - Segev, Shlomo
AU - Ozeri, David J.
AU - Veisman, Ido
AU - Lahat, Adi
AU - Laish, Ido
AU - Kopylov, Uri
AU - Oppenheim, Amit
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/3
Y1 - 2023/3
N2 - Background: The association between diverticular disease and atherosclerotic cardiovascular disease (ASCVD) has been demonstrated previously, mainly in symptomatic subjects. Aims: To evaluate 10 years cardiovascular risk, exercise performance and association to ASCVD among subjects with asymptomatic diverticulosis. Methods: A retrospective cross-sectional cohort of self-referred participants in a medical screening program, who underwent a screening colonoscopy. Demographics, clinical and laboratory variables, ASCVD score, and metabolic equivalents (METs) during treadmill stress test were compared between subjects with and without diverticulosis as diagnosed on screening colonoscopy. Results: 4586 participants underwent screening colonoscopy; 799 (17.4%) had diverticulosis. Among 50–69 yo participants, diverticulosis subjects had a higher ASCVD score compared to non-diverticulosis subjects. Exercise performance was comparable between the groups, across all age groups. Using logistic regression analysis, advanced age group (50–59 yo Adjusted odds ratio (AOR) [95% confidence interval (CI)] 2.57 (1.52–4.34), p < 0.001; 60–69 yo, AOR 2.87 (2.09–3.95), p < 0.001; ≥ 70 yo AOR 4.81 (3.23–7.15), p < 0.001; compared to < 50 yo age group), smoking [AOR 1.27 (1.05–1.55), p = 0.016], HTN [AOR 1.27 (1.03–1.56), p = 0.022], obesity [AOR 1.36 (1.06–1.74), p = 0.014] and male sex [AOR 1.29 (1.02–1.64), p = 0.036] were associated with diverticular detection during screening colonoscopy. Among males, achieving METs score ≥ 10 was inversely associated with diverticular detection during screening colonoscopy [AOR 0.64 (0.43–0.95), p = 0.027]. Conclusions: Ten years probability for ASCVD estimated by the ASCVD score is higher among subjects with asymptomatic diverticulosis compared to subjects without diverticulosis. Improved exercise performance is demonstrated for the first time to correlate with decreased probability for diverticular disease in screening colonoscopy.
AB - Background: The association between diverticular disease and atherosclerotic cardiovascular disease (ASCVD) has been demonstrated previously, mainly in symptomatic subjects. Aims: To evaluate 10 years cardiovascular risk, exercise performance and association to ASCVD among subjects with asymptomatic diverticulosis. Methods: A retrospective cross-sectional cohort of self-referred participants in a medical screening program, who underwent a screening colonoscopy. Demographics, clinical and laboratory variables, ASCVD score, and metabolic equivalents (METs) during treadmill stress test were compared between subjects with and without diverticulosis as diagnosed on screening colonoscopy. Results: 4586 participants underwent screening colonoscopy; 799 (17.4%) had diverticulosis. Among 50–69 yo participants, diverticulosis subjects had a higher ASCVD score compared to non-diverticulosis subjects. Exercise performance was comparable between the groups, across all age groups. Using logistic regression analysis, advanced age group (50–59 yo Adjusted odds ratio (AOR) [95% confidence interval (CI)] 2.57 (1.52–4.34), p < 0.001; 60–69 yo, AOR 2.87 (2.09–3.95), p < 0.001; ≥ 70 yo AOR 4.81 (3.23–7.15), p < 0.001; compared to < 50 yo age group), smoking [AOR 1.27 (1.05–1.55), p = 0.016], HTN [AOR 1.27 (1.03–1.56), p = 0.022], obesity [AOR 1.36 (1.06–1.74), p = 0.014] and male sex [AOR 1.29 (1.02–1.64), p = 0.036] were associated with diverticular detection during screening colonoscopy. Among males, achieving METs score ≥ 10 was inversely associated with diverticular detection during screening colonoscopy [AOR 0.64 (0.43–0.95), p = 0.027]. Conclusions: Ten years probability for ASCVD estimated by the ASCVD score is higher among subjects with asymptomatic diverticulosis compared to subjects without diverticulosis. Improved exercise performance is demonstrated for the first time to correlate with decreased probability for diverticular disease in screening colonoscopy.
KW - ASCVD
KW - Diverticulosis
KW - Exercise performance
KW - METs
KW - Screening colonoscopy
UR - http://www.scopus.com/inward/record.url?scp=85131856171&partnerID=8YFLogxK
U2 - 10.1007/s10620-022-07572-y
DO - 10.1007/s10620-022-07572-y
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C2 - 35695973
AN - SCOPUS:85131856171
SN - 0163-2116
VL - 68
SP - 902
EP - 912
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 3
ER -
