Cardiovascular aspects in Laron syndrome patients

Mickey Scheinowitz, Micha S. Feinberg, Michael Shechter, Zvi Laron*, Rivka Kauli

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

The chapter describes the role of congenital insulin-like growth factor I (IGF-I) deficiency, such as in patients with Laron syndrome, on cardiac function, exercise capacity, endothelial function, and intimal thickening. Despite small cardiac dimensions, heart function is normal, exercise capacity is significantly reduced and endothelial function is similar to that of normal controls. Brachial artery diameter was significantly smaller than controls but with no differences in endothelial function measures. Intimal thickening in the common carotid and internal carotid arteries was slightly higher in LS compared with normal controls. The data highlight the risks for cardiovascular disease in IGF-I deficiency.

Original languageEnglish
Title of host publicationLaron Syndrome - From Man to Mouse
Subtitle of host publicationLessons from Clinical and Experimental Experience
PublisherSpringer Berlin Heidelberg
Pages293-305
Number of pages13
ISBN (Print)9783642111822
DOIs
StatePublished - 2011

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