Cardiotoxic effects of the venom of the burrowing asp, Atractaspis engaddensis (Atractaspididae, Ophidia)

E. Weiser; Z. Wollberg; E. Kochva; S. Y. Lee

doi:10.1016/0041-0101(84)90159-4

Cardiotoxic effects of the venom of the burrowing asp, Atractaspis engaddensis (Atractaspididae, Ophidia)

E. Weiser^*, Z. Wollberg, E. Kochva, S. Y. Lee

^*Corresponding author for this work

School of Zoology

Research output: Contribution to journal › Article › peer-review

Abstract

The venom from the snake Atractaspis engaddensis has a very high lethal potency, with an i.v. ld₅₀ of 0.06 - 0.075 μg per g body weight in mice. The action of the venom is rapid and death results from seemingly neurotoxic effects. However, even at high concentrations, the venom does not block contractions of skeletal muscles that are directly or indirectly stimulated. The most prominent action of the venom is seen in the function of the heart in anesthetized mice, with or without artificial respiration. The changes observed in the ECG are similar to those recorded in human victims and are the result of an A-V block that is caused by an apparent direct action of the venom on the heart.

Original language	English
Pages (from-to)	767-774
Number of pages	8
Journal	Toxicon
Volume	22
Issue number	5
DOIs	https://doi.org/10.1016/0041-0101(84)90159-4
State	Published - 1984

Access to Document

10.1016/0041-0101(84)90159-4

Cite this

@article{200d952c452448d799343552053b9f81,

title = "Cardiotoxic effects of the venom of the burrowing asp, Atractaspis engaddensis (Atractaspididae, Ophidia)",

abstract = "The venom from the snake Atractaspis engaddensis has a very high lethal potency, with an i.v. ld50 of 0.06 - 0.075 μg per g body weight in mice. The action of the venom is rapid and death results from seemingly neurotoxic effects. However, even at high concentrations, the venom does not block contractions of skeletal muscles that are directly or indirectly stimulated. The most prominent action of the venom is seen in the function of the heart in anesthetized mice, with or without artificial respiration. The changes observed in the ECG are similar to those recorded in human victims and are the result of an A-V block that is caused by an apparent direct action of the venom on the heart.",

author = "E. Weiser and Z. Wollberg and E. Kochva and Lee, {S. Y.}",

year = "1984",

doi = "10.1016/0041-0101(84)90159-4",

language = "אנגלית",

volume = "22",

pages = "767--774",

journal = "Toxicon",

issn = "0041-0101",

publisher = "Elsevier Ltd.",

number = "5",

}

TY - JOUR

T1 - Cardiotoxic effects of the venom of the burrowing asp, Atractaspis engaddensis (Atractaspididae, Ophidia)

AU - Weiser, E.

AU - Wollberg, Z.

AU - Kochva, E.

AU - Lee, S. Y.

PY - 1984

Y1 - 1984

N2 - The venom from the snake Atractaspis engaddensis has a very high lethal potency, with an i.v. ld50 of 0.06 - 0.075 μg per g body weight in mice. The action of the venom is rapid and death results from seemingly neurotoxic effects. However, even at high concentrations, the venom does not block contractions of skeletal muscles that are directly or indirectly stimulated. The most prominent action of the venom is seen in the function of the heart in anesthetized mice, with or without artificial respiration. The changes observed in the ECG are similar to those recorded in human victims and are the result of an A-V block that is caused by an apparent direct action of the venom on the heart.

AB - The venom from the snake Atractaspis engaddensis has a very high lethal potency, with an i.v. ld50 of 0.06 - 0.075 μg per g body weight in mice. The action of the venom is rapid and death results from seemingly neurotoxic effects. However, even at high concentrations, the venom does not block contractions of skeletal muscles that are directly or indirectly stimulated. The most prominent action of the venom is seen in the function of the heart in anesthetized mice, with or without artificial respiration. The changes observed in the ECG are similar to those recorded in human victims and are the result of an A-V block that is caused by an apparent direct action of the venom on the heart.

UR - http://www.scopus.com/inward/record.url?scp=0021149315&partnerID=8YFLogxK

U2 - 10.1016/0041-0101(84)90159-4

DO - 10.1016/0041-0101(84)90159-4

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0021149315

SN - 0041-0101

VL - 22

SP - 767

EP - 774

JO - Toxicon

JF - Toxicon

IS - 5

ER -

Cardiotoxic effects of the venom of the burrowing asp, Atractaspis engaddensis (Atractaspididae, Ophidia)

Abstract

Access to Document

Other files and links

Fingerprint

Cite this