Cardiac sympathetic denervation preceding motor signs in Parkinson disease*

David S. Goldstein*, Yehonatan Sharabi, Barbara I. Karp, Oladi Bentho, Ahmed Saleem, Karel Pacak, Graeme Eisenhofer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.

Original languageEnglish
Pages (from-to)S47-S50
JournalCleveland Clinic Journal of Medicine
Issue numberSUPPL.2
StatePublished - 2009
Externally publishedYes


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