@article{7d8030320da54c3190f10006969943a3,
title = "Cardiac sympathetic denervation preceding motor signs in Parkinson disease",
abstract = "There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[ 18F]fluorodopamine-derived radioactivity and low baroreflex- cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.",
keywords = "Autonomic nervous system, Baroreflex, Heart, Imaging techniques, Parkinson disease, Sympathetic nervous system",
author = "Goldstein, {David S.} and Yehonatan Sharabi and Karp, {Barbara I.} and Oladi Bentho and Ahmed Saleem and Karel Pacak and Graeme Eisenhofer",
year = "2007",
month = apr,
doi = "10.1007/s10286-007-0396-1",
language = "אנגלית",
volume = "17",
pages = "118--121",
journal = "Clinical Autonomic Research",
issn = "0959-9851",
publisher = "D. Steinkopff-Verlag",
number = "2",
}