Cardiac surgery in patients with Hemophilia:is it safe?

Amjad Shalabi*, Erez Kachel, Alexander Kogan, Leonid Sternik, Liza Grosman-Rimon, Ronny Ben-Avi, Diab Ghanem, Eyalon Ram, Ehud Raanani, Mudi Misgav

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: The life expectancy of hemophiliacs is similar to that of the general population. As a result, the prevalence of age-related cardiovascular diseases has increased. We present our experience with hemophilia patients who underwent cardiac surgery in our Medical Center between 2004 and 2019. Methods: All hemophilia patients who underwent cardiac surgery were identified, and their peri-operative data evaluated retrospectively. Results: Ten patients were identified: six with hemophilia-A, one with hemophilia-B, and three with hemophilia-C (factor XI deficiency). Cardiac procedures included ten coronary artery bypass grafts and one aortic valve replacement. Hemophilia-A and B patients were treated with factor substitution, whereas patients with factor XI deficiency were treated with fresh frozen plasma. One patient died, and one patient suffered from non-active gastrointestinal bleeding. Conclusions: While major cardiac surgery can be performed safely on patients with hemophilia, a multidisciplinary team approach and strict postoperative monitoring are essential in order to achieve optimal results.

Original languageEnglish
Article number76
JournalJournal of Cardiothoracic Surgery
Issue number1
StatePublished - 8 May 2020
Externally publishedYes


  • Cardiac surgery
  • Cardiovascular disease
  • Factor XI deficiency
  • Hemophilia B
  • Hemophilia a


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