Cardiac denervation supersensitivity produced in guinea pigs by 6-hydroxy-dopamine

Sara Shavit, Sidney Gassner, Amos D. Korczyn*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of chemical sympathectomy with 6-hydroxydopamine (6-OH-DA) on the sensitivity of guinea-pig heart to catecholamines were studied. Heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy, while the arrhythmogenic effects of epinephrine, norepinep rine and isoprenaline were potentiated markedly. Our results indicate that chemical sympathectomy with 6-OH-DA produced post synaptic denervation supersensitivity in the heart ventricles.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalPharmacological Research Communications
Volume16
Issue number2
DOIs
StatePublished - Feb 1984

Funding

FundersFunder number
American Physicians Fellowship for the Israel Medical Association

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