TY - JOUR
T1 - Cardiac denervation supersensitivity produced in guinea pigs by 6-hydroxy-dopamine
AU - Shavit, Sara
AU - Gassner, Sidney
AU - Korczyn, Amos D.
N1 - Funding Information:
This research work was supported by a grant from the American Physicians Fellowship for the Israel Medical Association (Mifal Haverut Hutz).
PY - 1984/2
Y1 - 1984/2
N2 - The effects of chemical sympathectomy with 6-hydroxydopamine (6-OH-DA) on the sensitivity of guinea-pig heart to catecholamines were studied. Heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy, while the arrhythmogenic effects of epinephrine, norepinep rine and isoprenaline were potentiated markedly. Our results indicate that chemical sympathectomy with 6-OH-DA produced post synaptic denervation supersensitivity in the heart ventricles.
AB - The effects of chemical sympathectomy with 6-hydroxydopamine (6-OH-DA) on the sensitivity of guinea-pig heart to catecholamines were studied. Heart rate at rest and chronotropic effects of catecholamines remained unchanged after chemical sympathectomy, while the arrhythmogenic effects of epinephrine, norepinep rine and isoprenaline were potentiated markedly. Our results indicate that chemical sympathectomy with 6-OH-DA produced post synaptic denervation supersensitivity in the heart ventricles.
UR - http://www.scopus.com/inward/record.url?scp=0021331253&partnerID=8YFLogxK
U2 - 10.1016/S0031-6989(84)80092-2
DO - 10.1016/S0031-6989(84)80092-2
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AN - SCOPUS:0021331253
SN - 0031-6989
VL - 16
SP - 171
EP - 179
JO - Pharmacological Research Communications
JF - Pharmacological Research Communications
IS - 2
ER -