Carboplatin-degradation products formed under deliberated and non-deliberated laboratory experiments: Structural elucidation

Igal Gozlan, Adi Rotstein, Dror Avisar

Research output: Contribution to journalArticlepeer-review

Abstract

Carboplatin (CPT) is of undisputed relevance to cancer therapy. The formation of CPT degradation products (DPs) was studied in various aqueous solutions containing 100 μg/mL CPT. Three phosphate buffer solutions, at pH 4, pH 6, and pH 8, and three other solutions with the addition of NaCl, ammonia, and humic acids, were examined in deliberated and non-deliberated laboratory experiments. Nine CPT DPs were identified by their MS and UV spectra. Six (CPT1, 5, 6, 7, 8 and 9) were produced following exposure to solar irradiation, and mainly obtained from (CPT4) in the presence of the appropriate nucleophiles. Calculation of the first-order kinetics processes of CPT degradation enabled understanding the reaction mechanism for CPT4 formation through the intermediate product [CPT-NH3]+. The detection and quantification of DPs of other investigated drugs is recommended as an integral part of any study, method, or technique dealing with pharmaceutical residues in aquatic environments.

Original languageEnglish
Article number2196
JournalWater, Air, and Soil Pollution
Volume225
Issue number12
DOIs
StatePublished - 12 Nov 2014

Keywords

  • Carboplatin
  • Degradation product
  • Kinetics
  • LC-MS-UV
  • Nucleophile

Fingerprint

Dive into the research topics of 'Carboplatin-degradation products formed under deliberated and non-deliberated laboratory experiments: Structural elucidation'. Together they form a unique fingerprint.

Cite this