Carbapenem-resistant Enterobacteriaceae: Biology, epidemiology, and management

Elizabeth Temkin, Amos Adler, Anat Lerner, Yehuda Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.

Original languageEnglish
Pages (from-to)22-42
Number of pages21
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - 1 Sep 2014


  • Antimicrobial resistance
  • Carbapenem-resistant Enterobacteriaceae
  • Carbapenemases
  • Infection control
  • Molecular genetics
  • Treatment


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