Carbapenem-resistant Enterobacteriaceae: Biology, epidemiology, and management

Elizabeth Temkin, Amos Adler, Anat Lerner, Yehuda Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

185 Scopus citations

Abstract

Introduced in the 1980s, carbapenem antibiotics have served as the last line of defense against multidrug-resistant Gram-negative organisms. Over the last decade, carbapenem-resistant Enterobacteriaceae (CRE) have emerged as a significant public health threat. This review summarizes the molecular genetics, natural history, and epidemiology of CRE and discusses approaches to prevention and treatment.

Original languageEnglish
Pages (from-to)22-42
Number of pages21
JournalAnnals of the New York Academy of Sciences
Volume1323
Issue number1
DOIs
StatePublished - 1 Sep 2014

Funding

FundersFunder number
Seventh Framework Programme241796

    Keywords

    • Antimicrobial resistance
    • Carbapenem-resistant Enterobacteriaceae
    • Carbapenemases
    • Infection control
    • Molecular genetics
    • Treatment

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